Computer-Aided Drug Design and Delivery Systems
by: Ahindra Nag, Baishakhi Dey
Abstract: The latest breakthroughs in computer-aided drug design, drug delivery systems, and enabling technologies. Computer Aided Drug Design (CADD) and Delivery Systems offers an in-depth discussion of the computer-assisted techniques used to discover, design, and optimize new, effective, and safe drugs. Recent technological developments in biochemistry, biomedical science, and nanotechnology have made computer-aided drug design and delivery systems possible on a molecular basis. This in-depth treatise covers these pioneering advances. This text reviews all the enabling technologies such as bioinformatics, pharmacokinetics, biosensors, robotics, and bioinstrumentations. The progressive writing style allows you to establish solid fundamental knowledge of cell biology and utilization of the basics to applications such as drug delivery mechanisms and bioinstrumentations. Computer Aided Drug Design (CADD) and Delivery Systems features: Objective and quantitative data on the use of drugs in humans, Bioinformatics information with an emphasis computer-aided genome sequence modeling, Coverage of the latest pharmaceutical applications utilizing biochemical engineering, Practical examples of how recent advances in biochemistry are assisting new drug discovery and molecular-based drug delivery.
Full details
Table of Contents
- A. About the Authors
- B. Preface
- 1. Computer-Aided Drug Design (CADD)
- 2. Drug Delivery Systems
- 3. Bioinformatics of Drug Molecules and Databases
- 4. Lipase- and Esterase-Mediated Drugs and Drug Intermediates
- 5. Pharmacokinetics and Pharmacodynamics in Drugs
- 6. Biomarkers, Biosensors, and Robotics in Medicine
- 7. Biomedical Instrumentation
Tools & Media
Expanded Table of Contents
-
A.
About the Authors
-
B.
Preface
-
1.
Computer-Aided Drug Design (CADD)
- Introduction
- Rational Drug Design
- Factors Contributing to Drug Discovery
- Drug Design with the Help of Software
- Drug Discovery Process
- How Computers Help in Drug Design
- Computer Simulation for Drug Design
- Drug Design Theory
- Role of Computers in Drug Design: Their Success and Failure
- Rational Drug Design Software
- RACHEL Software Package
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2.
Drug Delivery Systems
- Introduction
- Development of Sustained-Release Drug Delivery Systems
- Important Physicochemical Properties of the Drug
- Biologic Properties
- Safety Considerations
- Transdermal Delivery Systems
- Targeted Delivery Systems
- Transdermal Delivery Systems
- Basic Components of Transdermal Devices
- Choice of Drug
- Excipients
- Adhesive and Packaging
- Pressure-Sensitive Adhesives
- Transdermal Devices
- In Vitro Release Kinetics
- In Vitro Skin-Permeation Kinetics
- IV-IV Correlation
- Optimization of Transdermal Systems
- Skin Irritation Sensitization
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3.
Bioinformatics of Drug Molecules and Databases
- Introduction
- The Concepts, Goals, and Aims of Bioinformatics
- Fields of Bioinformatics: Role and Relevance in Biotechnology
- Proteomics: Protein Sequence Databases
- Data Retrieval Systems
- System Retrieval Systems
- Applications of Bioinformatics
- Bioinformatics in Rational Drug Design and the Medical Sciences
- Bioinformatics and Chemical Engineering
- Brief Introduction to Bioinformatics Databases
- Microarray Database
- Bioinformatics Scenario
- 4. Lipase- and Esterase-Mediated Drugs and Drug Intermediates
- 5. Pharmacokinetics and Pharmacodynamics in Drugs
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6.
Biomarkers, Biosensors, and Robotics in Medicine
- Introduction
- Developmental History of Biomarkers
- Different Types of Biomarkers
- Use of Biomarkers in Cancer
- Biomarkers in Medical Science
- Recent Advances in Biomarkers
- Disadvantages of Biomarkers
- Biosensors
- Developmental History of Biosensors
- General Instrumentation and Operation of a Biosensor
- Biosensors in Drug Design
- Biosensors in Biomedical Research
- Robotics in Surgery
- Background and History of Surgical Robots
- Robot-Assisted Surgery
- Advantages and Disadvantages of Robot-Assisted Surgery
- Applications of Robotic Surgery
- Practical Uses of Surgical Robots Today
- Future of Robotic Surgery
- Conclusion
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7.
Biomedical Instrumentation
- Introduction
- Biomedical Instrumentation Measurements
- Measurement of Blood Flow and Cardiac Output
- Instrumentation for Psychophysiologic Measurements
- Instrumentation for the Experimental Analysis of Behavior
- Respiratory Therapy Equipment
- Pacemakers and Defibrillators
- Instrumentation for the Medical Use of Radioisotopes
- Ophthalmic and ENT Instruments
- Ultrasonography
- Computed Tomographic Scanning (CT Scanning)
- Positron-Emission Tomographic (PET) Scanning
- Magnetic Resonance Imaging
Book Details
Title: Computer-Aided Drug Design and Delivery Systems
Publisher: : New York, Chicago, San Francisco, Lisbon, London, Madrid, Mexico City, Milan, New Delhi, San Juan, Seoul, Singapore, Sydney, Toronto
Copyright / Pub. Date: 2011 The McGraw-Hill Companies, Inc
ISBN: 9780071701242
Authors:
Ahindra Nag is the author of this McGraw-Hill Professional publication.
Baishakhi Dey is the author of this McGraw-Hill Professional publication.
Description: The latest breakthroughs in computer-aided drug design, drug delivery systems, and enabling technologies. Computer Aided Drug Design (CADD) and Delivery Systems offers an in-depth discussion of the computer-assisted techniques used to discover, design, and optimize new, effective, and safe drugs. Recent technological developments in biochemistry, biomedical science, and nanotechnology have made computer-aided drug design and delivery systems possible on a molecular basis. This in-depth treatise covers these pioneering advances. This text reviews all the enabling technologies such as bioinformatics, pharmacokinetics, biosensors, robotics, and bioinstrumentations. The progressive writing style allows you to establish solid fundamental knowledge of cell biology and utilization of the basics to applications such as drug delivery mechanisms and bioinstrumentations. Computer Aided Drug Design (CADD) and Delivery Systems features: Objective and quantitative data on the use of drugs in humans, Bioinformatics information with an emphasis computer-aided genome sequence modeling, Coverage of the latest pharmaceutical applications utilizing biochemical engineering, Practical examples of how recent advances in biochemistry are assisting new drug discovery and molecular-based drug delivery.
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