Stem Cell Technologies: Basics and Applications
by: Satish Totey, Kaushik D. Deb
Abstract: Thorough coverage of the basics of stem cell technologies and applications. Stem cell-based therapies, also known as cell replacement therapies or regenerative medicine, provide the means to cure a host of diseases and disorders. Featuring 28 contributions from prestigious global experts, this book details the basics of stem cell biology and explores therapeutic and medical treatments stem cells can offer. The book covers embryonic and adult stem cells and includes a 32-page color insert with 70 color figures.
Full details
Table of Contents
- A. ABOUT THE EDITORS
- B. PRAISE FOR STEM CELL TECHNOLOGIES
- C. FOREWORD
- D. PREFACE
- 1. STEM CELLS AND REGENERATIVE MEDICINE—THE EVOLVING STORY
- 2. ZEBRAFISH STEM CELLS
- 3. MEDAKA STEM CELLS
- 4. CHICKEN EMBRYONIC STEM CELLS AS ANOTHER NON-MAMMALIAN EMBRYONIC STEM CELL TYPE
- 5. DERIVATION, CULTURE AND GENETIC MODIFICATION OF MOUSE EMBRYONIC STEM CELLS
- 6. DERIVATION OF HUMAN EMBRYONIC STEM CELLS FROM BLASTOCYSTS
- 7. DEVELOPING A SERUM-FREE PLATFORM AND A NOVEL REPORTER SYSTEM FOR hESCS
- 8. EPIGENETICS AND EMBRYONIC STEM CELLS
- 9. EMBRYONIC STEM CELLS AS A THERAPY FOR DIABETES
- 10. MANIPULATION OF BIOMATERIAL INTERFACE BY BIOMIMETIC STRATEGIES: POSSIBILITIES OF EXPLORING STEM CELLS
- 11. IMMUNOMODULATORY ASPECTS OF HUMAN EMBRYONIC AND ADULT STEM CELLS
- 12. HUMAN EMBRYONIC STEM CELLS AS A MODEL SYSTEM TO STUDY HUMAN GENETICS
- 13. GERM CELLS AND ARTIFICIAL GAMETES PRODUCTION FROM EMBRYONIC STEM CELLS
- 14. USING EMBRYONIC STEM CELLS TO INTRODUCE MUTATIONS INTO THE MOUSE GERM LINE: ANIMAL MODELS AND FUTURE APPLICATIONS
- 15. APPLICATION OF HUMAN EMBRYONIC STEM CELLS IN DRUG DISCOVERY
- 16. RECENT ADVANCEMENTS IN TISSUE-RESIDENT ADULT STEM/PROGENITOR CELL BIOLOGY AND THEIR THERAPEUTIC APPLICATIONS IN REGENERATIVE MEDICINE AND CANCER THERAPIES
- 17. MESENCHYMAL STEM CELLS AND THEIR THERAPEUTIC POTENTIAL IN THE NERVOUS SYSTEM
- 18. MESENCHYMAL STEM CELLS: BIOLOGY, CULTURE OPTIMISATION, AND POTENTIAL CLINICAL USE
- 19. MESENCHYMAL STEM CELLS: CULTURE, CHARACTERISATION, AND THERAPEUTIC APPLICATIONS IN NEURODEGENERATIVE DISEASES
- 20. DENTAL PULP STEM CELLS AND PERSPECTIVES OF FUTURE APPLICATION IN CELL THERAPY
- 21. HEMATOPOIETIC STEM CELLS AND THEIR DYNAMICS
- 22. SPERMATOGONIAL STEM CELLS
- 23. EPIGENETICS AS A CAUSE FOR THE ELOQUENT SILENCE OF STEM CELLS
- 24. CANCER STEM CELLS: THE ENEMY WITHIN CANCERS
- 25. EXPLORING THE POTENTIAL OF ADULT STEM CELLS: WHY UMBILICAL CORD BLOOD?
- 26. CELL THERAPY AND TISSUE ENGINEERING STRATEGIES IN REGENERATIVE MEDICINE
- 27. BIOMATERIALS FOR ENHANCING CORNEAS AND SPINAL CORD REGENERATION
- A. COLOR PLATES
Tools & Media
Expanded Table of Contents
-
A.
ABOUT THE EDITORS
-
B.
PRAISE FOR STEM CELL TECHNOLOGIES
-
C.
FOREWORD
-
D.
PREFACE
- 1. STEM CELLS AND REGENERATIVE MEDICINE—THE EVOLVING STORY
-
2.
ZEBRAFISH STEM CELLS
- INTRODUCTION
- PROTOCOL FOR THE INITIATION AND MAINTENANCE OF ZEBRAFISH PRIMARY EMBRYO CELL CULTURES
- DERIVATION OF ZEBRAFISH ESC CULTURES
- GERM-LINE CHIMERA PRODUCTION FROM ES CELL CULTURES
- HOMOLOGOUS RECOMBINATION IN THE ZEBRAFISH ES CELL CULTURES
- DERIVATION OF ZEBRAFISH PGC CULTURE
- PGC ISOLATION
- FREQUENCY OF ZEBRAFISH GERM-LINE CHIMERA PRODUCTION FROM PGC CULTURES
- CONCLUSION
- ACKNOWLEDGEMENTS
- 3. MEDAKA STEM CELLS
-
4.
CHICKEN EMBRYONIC STEM CELLS AS ANOTHER NON-MAMMALIAN EMBRYONIC STEM CELL TYPE
- INTRODUCTION: TOTIPOTENCY AND PLURIPOTENCY IN ANIMAL CELLS
- MOUSE EMBRYONIC STEM CELLS AS ESC ARCHETYPE
- PLURIPOTENCY AND ISOLATION OF EMBRYONIC STEM CELLS IN BIRDS
- BIOCHEMICAL CHARACTERISATION
- IN VITRO DIFFERENTIATION POTENTIALITIES
- GENETIC MODIFICATION
- IN VIVO CHIMERISM
- GERM-LINE COMPETENCY AND IN VIVO CONTRIBUTION OF CESC
- MOLECULAR CHARACTERISATION OF CHICKEN PLURIPOTENCY: OCT4 IS ALSO PRESENT IN CHICKEN
- PRESENCE OF OCT4 IN NON-MAMMALIAN SPECIES
- THE NANOG HOMEODOMAIN GENE IS ALSO PRESENT IN CHICKEN
- INDUSTRIAL INTEREST OF AVIAN STEM CELLS
- CONCLUSION
- 5. DERIVATION, CULTURE AND GENETIC MODIFICATION OF MOUSE EMBRYONIC STEM CELLS
- 6. DERIVATION OF HUMAN EMBRYONIC STEM CELLS FROM BLASTOCYSTS
- 7. DEVELOPING A SERUM-FREE PLATFORM AND A NOVEL REPORTER SYSTEM FOR hESCS
- 8. EPIGENETICS AND EMBRYONIC STEM CELLS
-
9.
EMBRYONIC STEM CELLS AS A THERAPY FOR DIABETES
- INTRODUCTION
- ALTERNATIVE β-CELL REPLACEMENT THERAPIES
- NON-ONTOGENY-BASED DIFFERENTIATION OF ESCs INTO INSULIN-PRODUCING β-CELLS
- LIMITATIONS IN NON-ONTOGENY BASED DIFFERENTIATION STRATEGIES
- THE GENERATION OF DEFINITIVE ENDODERM FROM PLURIPOTENT CELLS
- DEVELOPMENT OF THE PRIMITIVE GUT TUBE FROM DEFINITIVE ENDODERM
- PRODUCTION OF PDX-1-EXPRESSING PANCREATIC PROGENITOR CELLS
- DIFFERENTIATION OF PANCREATIC PROGENITOR CELLS TO ENDOCRINE CELLS
- ENDOCRINE CELL SPECIFICATION TO MATURE INSULIN-PRODUCING β-CELLS
- OTHER APPROACHES TO EMBRYONIC STEM CELL DIFFERENTIATION INTO INSULIN-PRODUCING β-CELLS
- THE FUTURE
- CONCLUSION
- ACKNOWLEDGEMENTS
-
10.
MANIPULATION OF BIOMATERIAL INTERFACE BY BIOMIMETIC STRATEGIES: POSSIBILITIES OF EXPLORING
STEM CELLS
- INTRODUCTION
- STEM CELLS: ORIGIN AND EXPLORATION FOR TISSUE ENGINEERING AND REGENERATIVE MEDICINE
- INFLAMMATION AT AN IMPLANT SITE
- STEM CELL BEHAVIOUR IN RELATION TO INFLAMMATORY RESPONSE
- STEM CELLS AND CHRONIC INFLAMMATION
- STEM CELLS AND CONTROLLED DIFFERENTIATION
- STEM CELLS AND ENGRAFTMENT
- STEM CELLS AND ANGIOGENESIS
- STEM CELL BEHAVIOUR IN RELATION TO IMMUNE RESPONSE
- MODULATING IMMUNE RESPONSE: A LESSON FROM FOETAL ENGRAFTMENT [ 38]
- SURFACE THE CULPRIT
- STEM CELL INTERACTION WITH BIOMATERIALS
- BIOMIMETIC APPROACHES IN SURFACE MODIFICATION USING DENSE THIN SOLID FILMS
- OPTIMISATION OF HETEROGENEOUS BIOMIMETIC LIPID COMPOSITION
- STEM CELL ADHESION AND PROLIFERATION STUDIES
- CONCLUSION
- ACKNOWLEDGEMENTS
- 11. IMMUNOMODULATORY ASPECTS OF HUMAN EMBRYONIC AND ADULT STEM CELLS
- 12. HUMAN EMBRYONIC STEM CELLS AS A MODEL SYSTEM TO STUDY HUMAN GENETICS
- 13. GERM CELLS AND ARTIFICIAL GAMETES PRODUCTION FROM EMBRYONIC STEM CELLS
- 14. USING EMBRYONIC STEM CELLS TO INTRODUCE MUTATIONS INTO THE MOUSE GERM LINE: ANIMAL MODELS AND FUTURE APPLICATIONS
-
15.
APPLICATION OF HUMAN EMBRYONIC STEM CELLS IN DRUG DISCOVERY
- INTRODUCTION
- ISOLATION, PROPAGATION AND CHARACTERISATION OF hESCs
- SPONTANEOUS DIFFERENTIATION OF hESCs
- DRAWBACKS WITH hESCs IN REGENERATIVE MEDICINE
- hESCs IN DRUG DISCOVERY AND DEVELOPMENT
- DEVELOPMENTAL TOXICITY
- MEASUREMENT CRITERIA
- DIFFERENTIAL GENE EXPRESSION DURING EB DEVELOPMENT
- CYTOTOXICITY
- ROLE OF GENETICALLY MODIFIED hESCs IN TOXICITY SCREENING
- APPLICATION FOR CARDIOMYOCYTES DERIVED FROM hESCs
- CARDIOMYOCYTES: DERIVATION AND CHARACTERISTICS
- CARDIOMYOCYTES: SAFETY PHARMACOLOGY AND DISCOVERY OF NOVEL DRUG TARGETS
- APPLICATION FOR HEPATOCYTES DERIVED FROM hESCs
- HEPATOCYTES: DERIVATION AND CHARACTERISTICS
- HEPATOCYTES: STUDIES OF DRUG METABOLISM AND DRUG-INDUCED HEPATOTOXICITY
- CONCLUSION
- 16. RECENT ADVANCEMENTS IN TISSUE-RESIDENT ADULT STEM/PROGENITOR CELL BIOLOGY AND THEIR THERAPEUTIC APPLICATIONS IN REGENERATIVE MEDICINE AND CANCER THERAPIES
-
17.
MESENCHYMAL STEM CELLS AND THEIR THERAPEUTIC POTENTIAL IN THE NERVOUS SYSTEM
- INTRODUCTION
- POTENTIAL THERAPEUTIC APPLICATIONS OF MSCs
- MSC-BASED THERAPY IN THE TREATMENT OF OSSEOUS AND ADIPOSE TISSUE DEFECTS
- MSC-BASED THERAPY IN THE TREATMENT OF NEUROLOGICAL DEFICITS
- MECHANISMS BY WHICH TRANSPLANTED MSCs ELICIT FUNCTIONAL RECOVERY IN THE DAMAGED NERVOUS SYSTEM
- IN VITRO ‘TRANS’-DIFFERENTIATION OF MSCs INTO NEURAL CELL TYPES
- IN VITRO ‘TRANS’-DIFFERENTIATION OF MSCs INTO NEURAL CELL TYPES—AN ARTEFACT OF CELL CULTURE?
- IN VIVO ‘TRANS’-DIFFERENTIATION OF MSCs INTO NEURAL CELL TYPES
- SPONTANEOUS CELL FUSION OF MSCs WITH HOST NEURAL CELLS
- MSCs AS TROPHIC MEDIATORS OF NEURAL DIFFERENTIATION
- SECRETION OF NEUROTROPHIC FACTORS BY MSCs
- SECRETION OF NON-NEUROTROPHIC FACTORS BY MSCs
- ANALYSIS OF MSC-DERIVED SOLUBLE FACTORS IN VITRO: A CONDITIONED MEDIA APPROACH
- 18. MESENCHYMAL STEM CELLS: BIOLOGY, CULTURE OPTIMISATION, AND POTENTIAL CLINICAL USE
- 19. MESENCHYMAL STEM CELLS: CULTURE, CHARACTERISATION, AND THERAPEUTIC APPLICATIONS IN NEURODEGENERATIVE DISEASES
- 20. DENTAL PULP STEM CELLS AND PERSPECTIVES OF FUTURE APPLICATION IN CELL THERAPY
-
21.
HEMATOPOIETIC STEM CELLS AND THEIR DYNAMICS
- INTRODUCTION
- EVIDENCE FOR HEMATOPOIETIC STEM CELLS
- PROPERTIES OF HAEMATOPOIETIC STEM CELLS
- SOURCES OF HAEMATOPOIETIC STEM CELLS
- THE STEM CELL NICHE
- HOW MANY STEM CELLS?
- EXPANSION OF THE HSC DURING HUMAN ONTOGENY
- STEM CELL AGING/CLONAL SUCCESSION
- STOCHASTIC DYNAMICS WITHIN THE HSC POOL
- SYMMETRY OF STEM CELL REPLICATION AND FITNESS
- STEM CELL POOL, LONGEVITY AND CANCER
- INHERITED AND ACQUIRED HAEMATOPOIETIC STEM CELL DISORDERS
- ACQUIRED HAEMATOPOIETIC STEM CELLS DISORDERS WITH CML AND PNH AS PROTOTYPES
- FUTURE DEVELOPMENTS
- ACKNOWLEDGEMENTS
-
22.
SPERMATOGONIAL STEM CELLS
- INTRODUCTION
- BASIC PRINCIPLES AND JARGONS RELATED TO SPERMATOGONIAL STEM CELLS
- TESTICULAR COMPARTMENT AND CELLULAR INTERACTION
- PROLIFERATION AND DIFFERENTIATION OF SSCs
- REGULATION OF SSCs DEVELOPMENT
- CURRENT STATUS OF THE RESEARCH
- MARKERS EXPRESS ON SSCs DURING THEIR DEVELOPMENT
- FUTURE APPLICATIONS AND CAUTION
- CONCLUSION
- 23. EPIGENETICS AS A CAUSE FOR THE ELOQUENT SILENCE OF STEM CELLS
-
24.
CANCER STEM CELLS: THE ENEMY WITHIN CANCERS
- INTRODUCTION TO CANCER
- CLONALITY IN CANCER
- CANCER HETEROGENEITY
- STOCHASTIC AND HIERARCHY MODELS
- STEM CELLS AND HIERARCHY
- CANCER STEM CELLS
- TECHNIQUES USED TO ISOLATE CSCs
- TECHNIQUES USED TO ASSESS CSCs
- IDENTIFICATION AND ISOLATION OF CSCs FROM SOLID TUMOURS
- CSCs AND METASTASIS
- CELL OF ORIGIN OF CSC
- THERAPEUTIC IMPLICATIONS OF CSCs
- FUTURE DIRECTIONS
- DEFINITIONS OF IMPORTANT TERMS
-
25.
EXPLORING THE POTENTIAL OF ADULT STEM CELLS: WHY UMBILICAL CORD BLOOD?
- INTRODUCTION
- UMBILICAL CORD BLOOD IS AN IMPORTANT SOURCE OF STEM CELLS
- UMBILICAL CORD BLOOD STEM CELLS AND TRANSPLANTS
- GENERAL AND ETHICAL TOPICS ABOUT UCB BANKING
- UMBILICAL CORD BLOOD AS A SOURCE OF MESENCHYMAL STEM CELLS
- UMBILICAL CORD DERIVED STEM CELLS FOR TISSUE THERAPY: CURRENT STATUS AND PERSPECTIVES
- 26. CELL THERAPY AND TISSUE ENGINEERING STRATEGIES IN REGENERATIVE MEDICINE
- 27. BIOMATERIALS FOR ENHANCING CORNEAS AND SPINAL CORD REGENERATION
-
A.
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Book Details
Title: Stem Cell Technologies: Basics and Applications
Publisher: McGraw-Hill: New York, Chicago, San Francisco, Lisbon, London, Madrid, Mexico City, Milan, New Delhi, San Juan, Seoul, Singapore, Sydney, Toronto
ISBN: 9780071635721
Authors:
Satish Totey is the author of this McGraw-Hill Professional publication.
Kaushik D. Deb is the author of this McGraw-Hill Professional publication.
Description: Thorough coverage of the basics of stem cell technologies and applications. Stem cell-based therapies, also known as cell replacement therapies or regenerative medicine, provide the means to cure a host of diseases and disorders. Featuring 28 contributions from prestigious global experts, this book details the basics of stem cell biology and explores therapeutic and medical treatments stem cells can offer. The book covers embryonic and adult stem cells and includes a 32-page color insert with 70 color figures.
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